Eine Auswahl unserer Publikationen zu den Themen Placebo- und Noceboantwort:

Kirchhof J, Petrakova L, Brinkhoff A, Benson S, Schmidt J, Unteroberdörster M, Wilde B, Kaptchuk TJ, Witzke O, Schedlowski M.
Learned immunosuppressive placebo responses in renal transplant patients.
Proc Natl Acad Sci. 2018; 115:4223-4227

Roderigo T, Benson S, Schöls M, Hetkamp M, Schedlowski M, Enck P, Elsenbruch S.
Effects of acute psychological stress on placebo and nocebo responses in a clinically relevant model of viseroception
Pain. 2017;1489-1498

Zunhammer M, Ploner M, Engelbrecht C, Bock J, Kessner S, Bingel U.

The effects of treatment failure generalize across different routes of drug administration
Sci Transl Med. 2017;9:393.

Enck P, Chae Y, Elsenbruch S.
Novel designs and paradigms to study the placebo responce in gastroenterology
Curr Opin Pharmacol. 2017;72-79

Rief W, Shedden-Mora MC, Laferton JA, Auer C, Petrie KJ, Salzmann S, Schedlowski M, Moosdorf R.
Preoperative optimization of patient expectations improves long-term outcome in heart surgery patients: results of the randomized controlled PSY-HEART trial.
BMC Med. 2017;15:4.

Engler H, Brendt P, Wischermann J, Wegner A, Röhling R, Schoemberg T, Meyer U, Gold R, Peters P, Benson S, Schedlowski M.
Selective increase of cerebrospinal fluid IL-6 during experimental endotoxemia in humans: association with depressive symptoms.
Mol Psychiatry. 2017; Epub ahead of print

Nestoriuc Y, von Blanckenburg P, Schuricht F, Barsky AJ, Hadji P, Albert US, Rief W.
Is it best to expect the worst? Influence of patients' side-effect expectations on endocrine treatment outcome in a 2-year prospective clinical cohort study.
Ann Oncol. 2016;1909-15.

Doering BK, Wegner A, Hadamitzky M, Engler H, Rief W, Schedlowski M.
Effects of neurexan in an experimental acute stress setting - an explorative double-blind study in healthy volunteers.
Life Sci. 2016;46:139-47.

Engler H, Benson S, Wegner A, Spreitzer I, Schedlowski M, Elsenbruch S.
Men and women differ in inflammatory and neuroendocrine responses to endotoxin but not in the severity of sickness symptoms.
Brain Behav Immun. 2016;52:18-26

Elsenbruch S, Enck P.
Placebo effects and their determinants in gastrointestinal disorders.
Nat Rev Gastroenterol Hepatol 12, 472-85, 2015

Schedlowski M, Enck P, Rief W, Bingel U.
Neuro-Bio-Behavioral Mechanisms of Placebo nd Nocebo Responses: Implications for Clinical Trials and Clinical Practice.
Pharmacol Rev, 697-730, 2015

Bingel U; For the Placebo Competence Team.
Avoiding Nocebo Effects to Optimize Treatment Outcome.
JAMA 2014

Enck P, Bingel U, Schedlowski M, Rief W.

The placebo response in medicine: minimize, maximize or personalize.
Nature Review Drug Discovery 12, 191-204, 2013.

Rief W, Bingel U, Schedlowski M, Enck P.
Mechanisms involved in placebo and nocebo responses and implications for drug trials.
Clinical Pharmacology & Therapeutics 90, 722-26, 2011.

Auswahl der Publikationen der einzelnen Arbeitsgruppen/
Selection of publications of the specific research groups


Bingel U, Wanigasekera V, Wiech K, Ni Mhuircheartaigh R, Lee MC, Ploner M, et al.
The effect of treatment expectation on drug efficacy: Imaging the analgesic benefit of the opioid remifentanil.
Science Translational Medicine 3, 70ra 14, 2011.

Bingel U, Colloca L, & Vase L.
Mechanisms and clinical implications of the placebo effect: Is there a potential for the elderly? A mini-review.
Gerontology 57, 354-63, 2010.

Eippert F, Finsterbusch J, Bingel U, Buchel C.
Direct evidence for spinal cord involvement in placebo analgesia.
Science 326, 404, 2009.

Eippert F, Bingel U, Schoell ED, Yacubian J, Klinger R, Lorenz J, et al.
Activation of the opioidergic descending pain control system underlies placebo analgesia.
Neuron 63, 533-43, 2009

Bingel U, Tracey I.
Imaging CNS modulation of pain in humans.
Physiology 23, 371-80, 2008


Weimer K, Colloca L, Enck P.
Placebo effects in psychiatry: mediators and moderators
Lancet Psychiatry, 246-57, 2015

Horing B, Weimer K, Muth ER, Enck P.
Prediction of placebo responses: a systematic review of the literature.
Front Psychol 1,5:1079, 2014

Weimer K, Enck P.
Traditional and innovative experimental and clinical trial designs and their advantages and pitfalls.
Handb Exp Pharmacol, 237-72, 2014

Horing B, Weimer K, Schrade D, Muth ER, Scisco JL, Enck P, Klosterhalfen S.
Reduction of motion sickness with an enhanced placebo instruction: an experimental study with healthy participants.
Psychosom Med. 75, 497-504, 2013

Weimer K, Horing B, Stürmer J, Klosterhalfen S, Zipfel S, Enck P. Nicotine
stimulus expectancy differentially affects reaction time in healthy nonsmokers and smokers depending on sex: a pilot study.
Exp Clin Psychopharmacol. 21, 181-7, 2013

Weimer K, Gulewitsch MD, Schlarb AA, Schwille-Kiuntke J, Klosterhalfen S, Enck P.
Placebo effects in children: a review.
Pediatr Res. 74, 96-102, 2013


Rief W, Glombiewski JA, Gollwitzer M, Schubö A, Schwarting R, Thorwart A.
Expectancies as core features of mental disorders.
Curr Opin Psychiatry, 2015

Glombiewski JA, Nestoriuc Y, Rief W, Glaesmer H & Braehler E.
Medication adherence in the general population.
PLoS One 7, 2013.

Doering BK, Rief W.
Utilizing placebo mechanisms for dose reduction in pharmacotherapy
Trends Pharmacol Sci 33, 165-72, 2012.

Rief W, Glombiewski JA.
The hidden effects of blinded, placebo controlled randomized trials: An experimental investigation.
Pain 153, 2473-77, 2012.

Rief W, Barsky AJ, Glombiewski JA, Nestoriuc Y, Glaesmer H & Brähler E.
Assessing general side effects in clinical trials: Reference data from the general population.
Pharmacoepidemiology & Drug Safety 20, 405-415, 2011.

Shedden Mora MC, Nestoriuc Y & Rief W.
Lessions learned from placebo groups in antidepressant trials.
Philosophical Transactions of the Royal Society B (Biological Sciences) 366, 1879-1888, 2011.


Wendt L, Albring A, Benson S, Engler H, Engler A, Hinney A, Rief W, Witzke O, Schedlowski M.
Catechol-O-methyltransferase Val158Met polymorphism is associated with somatosensory amplification and nocebo responses.
PLoS One 15, 2014.

Albring A, Wendt L, Benson S, Nissen S, Yavuz Z, Engler H, Witzke O, Schedlowski M.
Preserving learned immunosuppressive placebo response: perspectives for clinical application.
Clinical Pharmacology & Therapeutics 96, 247-255, 2014 .

Vits S, Cesko E, Benson S, Rueckert A, Hillen U, Schadendorf D, Schedlowski M.
Cognitive factors mediate placebo responses in patients with house dust mite allergy.
PloS One 18, 2013.

Ober K, Benson S, Vogelsang M, Bylica A, Günther D, Witzke O, Kribben A, Engler H, Schedlowski M.
Plasma Noradrenaline and State Anxiety Levels Predict Placebo Response in Learned Immunosuppression.
Clinical Pharmacology & Therapeutics 91, 220-26, 2012.

Wirth T, Ober K, Prager G, Vogelsang M, Benson S, Witzke O, Kribben A, Engler H, Schedlowski M.
Repeated recall of learned immunosuppression: Evidence from rats and men.
Brain Behavior & Immunity 25, 1444-51, 2011.